Voriconazole: The Newest Triazole Antifungal Agent
نویسندگان
چکیده
منابع مشابه
Voriconazole: the newest triazole antifungal agent.
BUMC PROCEEDINGS 2003;16:241–248 Fungal infections remain a significant cause of morbidity and mortality despite advances in medicine and the emergence of new antifungal agents (1). Immunocompromised patients are particularly at risk of developing these infections, with Candida and Aspergillus spp. being the mycoses most commonly identified (2). Patients who develop candidemia have a greater ch...
متن کاملVoriconazole: a new triazole antifungal agent.
Voriconazole is a second-generation azole antifungal agent that shows excellent in vitro activity against a wide variety of yeasts and molds. It can be given by either the intravenous or the oral route; the oral formulation has excellent bioavailability. The side effect profile of voriconazole is unique in that non-sight-threatening, transient visual disturbances occur in approximately 30% of p...
متن کاملVoriconazole: a new triazole antifungal.
OBJECTIVE To review the currently available information on the pharmacology, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage guidelines of voriconazole. Comparative data for voriconazole and other azole antifungal agents are described where available. DATA SOURCES A MEDLINE search restricted to English-language articles (1966 to September 1999) was conducted, and an...
متن کاملPosaconazole (Noxafil): a new triazole antifungal agent.
Posaconazole is the newest triazole antifungal agent. It is structurally related to itraconazole and has activity against Candida species, Aspergillus species, Cryptococcus neoformans, the zygomycetes, and other filamentous fungi. Randomized, double-blind trials have shown posaconazole to be at least as efficacious as fluconazole for the prevention of invasive fungal infections in immunocomprom...
متن کاملSynthesis of Isomeric and Potent Impurities of the Triazole-Based Antifungal Drug Voriconazole.
We describe the synthesis of two positional isomers and a desfluoro impurity of Voriconazole starting with Friedel-Crafts acylation of mono- and difluorobenzene. These isomers are the crucial components in determining the quality of Voriconazole during its manufacturing from the key raw material, 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one. All the prepared impurities were chara...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Baylor University Medical Center Proceedings
سال: 2003
ISSN: 0899-8280,1525-3252
DOI: 10.1080/08998280.2003.11927910